An adult presents to the emergency department with acute asthma is chartered the following dose of prednisone 90mg/a day for 2 days, then 50mg/day for 2 days, then 20mg/day for 2 days then stop. The drug is supplied as 20mg and 10mg tablets 1) the number of 20mg and 10 mg prednisone tablets to be given for each dose 2) the total number of 20mg and 10mg tablets needed for 6 days 3) the total amount of prednisone required for the 6 days expressed in grams expressed correctly and clearly in sentence form

Let's break this down step by step to calculate the number of 20mg and 10mg tablets needed, as well as the total amount of prednisone for the 6-day course.

### 1. **The number of 20mg and 10mg prednisone tablets to be given for each dose:**

#### Days 1-2 (90mg/day):
- Each day, the dose is 90mg.
- The drug is available in 20mg and 10mg tablets.

To make up 90mg:
- Use 4 tablets of 20mg (4 * 20mg = 80mg).
- Use 1 tablet of 10mg (1 * 10mg = 10mg).
- Total for each day: 4 tablets of 20mg and 1 tablet of 10mg.

#### Days 3-4 (50mg/day):
- Each day, the dose is 50mg.

To make up 50mg:
- Use 2 tablets of 20mg (2 * 20mg = 40mg).
- Use 1 tablet of 10mg (1 * 10mg = 10mg).
- Total for each day: 2 tablets of 20mg and 1 tablet of 10mg.

#### Days 5-6 (20mg/day):
- Each day, the dose is 20mg.

To make up 20mg:
- Use 1 tablet of 20mg (1 * 20mg = 20mg).
- Total for each day: 1 tablet of 20mg and 0 tablets of 10mg.

### 2. **Total number of 20mg and 10mg tablets needed for 6 days:**

Now let's calculate the total number of tablets for the 6 days.

- **Days 1-2 (90mg/day):**
  - 4 tablets of 20mg/day × 2 days = 8 tablets of 20mg.
  - 1 tablet of 10mg/day × 2 days = 2 tablets of 10mg.

- **Days 3-4 (50mg/day):**
  - 2 tablets of 20mg/day × 2 days = 4 tablets of 20mg.
  - 1 tablet of 10mg/day × 2 days = 2 tablets of 10mg.

- **Days 5-6 (20mg/day):**
  - 1 tablet of 20mg/day × 2 days = 2 tablets of 20mg.
  - No 10mg tablets needed.

**Total tablets over 6 days:**
- 20mg tablets: 8 (days 1-2) + 4 (days 3-4) + 2 (days 5-6) = **14 tablets of 20mg**.
- 10mg tablets: 2 (days 1-2) + 2 (days 3-4) = **4 tablets of 10mg**.

### 3. **The total amount of prednisone required for 6 days expressed in grams:**

- Days 1-2: 90mg/day × 2 days = 180mg.
- Days 3-4: 50mg/day × 2 days = 100mg.
- Days 5-6: 20mg/day × 2 days = 40mg.

**Total amount of prednisone:**
- 180mg + 100mg + 40mg = **320mg**.

Since 1 gram = 1000mg, the total amount of prednisone required is:
- **320mg = 0.32 grams**.

### Final Answer:

- For each dose:
  - Days 1-2: 4 tablets of 20mg and 1 tablet of 10mg.
  - Days 3-4: 2 tablets of 20mg and 1 tablet of 10mg.
  - Days 5-6: 1 tablet of 20mg.

- Total tablets for 6 days:
  - **14 tablets of 20mg**.
  - **4 tablets of 10mg**.

- The total amount of prednisone required over the 6 days is **0.32 grams**.

Would you like further details or have any questions?

Here are 5 follow-up questions to enhance your understanding:
1. How would prednisone doses differ for chronic asthma management versus acute episodes?
2. What side effects should be monitored with high-dose short-term prednisone use?
3. How does prednisone interact with other medications typically prescribed for asthma?
4. What tapering strategies might be used for longer prednisone treatments?
5. How is prednisone metabolized, and what factors affect its bioavailability?

**Tip:** Prednisone is a glucocorticoid, so it’s crucial to monitor for signs of adrenal suppression when using it for extended periods.

Calculate the number of 20mg and 10mg prednisone tablets for a 6-day acute asthma treatment course. Includes dose breakdown, total tablet count, and total prednisone amount in grams. Suitable for high school students studying arithmetic and unit conversions.

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