M:
[
54 - (72 - 45) + [38 - (25 - 12)] = 54 - 27 + [38 - 13] = 54 - 27 + 25 = 52
]

N
N:
[
48 - {50 - (45 - [37 - 15])} = 48 - {50 - (45 - 22)} = 48 - {50 - 23} = 48 - 27 = 21
]

P
P:
[
41 - [(24 + 35) - (18 + 21)] = 41 - [59 - 39] = 41 - 20 = 21
]

E
E:
[
E = 21 \times [52 - (21 + 13)] + 2 = 21 \times (52 - 34) + 2 = 21 \times 18 + 2 = 378 + 2 = 380
]

Esto nos lleva a 
E
=
380
E=380. porque dice times

Let's carefully analyze the steps one by one, particularly focusing on the last part.

You provided the expressions for \( M \), \( N \), and \( P \), and now we're calculating \( E \). The key is how the operations are carried out, especially multiplication (indicated by "times") and parentheses.

### Expression for \( E \):

\[
E = 21 \times [52 - (21 + 13)] + 2
\]

Let's break this down step by step:

1. **Parentheses first**:
   \[
   21 + 13 = 34
   \]
   So,
   \[
   52 - 34 = 18
   \]

2. **Multiplication next**:
   \[
   21 \times 18 = 378
   \]

3. **Final addition**:
   \[
   378 + 2 = 380
   \]

Thus, \( E = 380 \).

The word "times" indicates multiplication (between \( 21 \) and \( 18 \)), which is correctly applied in the given solution.

### Summary:
The final result of \( E \) is indeed **380**.

Would you like further clarification on any part of the process or the other expressions?

### 5 Follow-up Questions:
1. Would you like to see more detailed steps for solving \( M \), \( N \), or \( P \)?
2. Do you need help understanding why parentheses are prioritized in operations?
3. Should I explain why multiplication is performed before addition in this expression?
4. Would you like to see how this relates to other mathematical rules like order of operations (PEMDAS)?
5. Do you need any specific examples of using parentheses and brackets in different scenarios?

### Tip:
Always remember to follow the order of operations: parentheses first, then multiplication/division, and finally addition/subtraction (PEMDAS).

54 - (72 - 45) + [38 - (25 - 12)] = 54 - 27 + [38 - 13] = 54 - 27 + 25 = 52
48 - {50 - (45 - [37 - 15])} = 48 - {50 - (45 - 22)} = 48 - {50 - 23} = 48 - 27 = 21
41 - [(24 + 35) - (18 + 21)] = 41 - [59 - 39] = 41 - 20 = 21
E = 21 × [52 - (21 + 13)] + 2 = 21 × (52 - 34) + 2 = 21 × 18 + 2 = 378 + 2 = 380

This page explains how to solve complex arithmetic expressions using the order of operations (PEMDAS). Follow detailed steps to understand the role of parentheses, multiplication, and addition in solving problems such as E = 21 × [52 - (21 + 13)] + 2 = 380. Suitable for students in Grades 6-8.

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